Another double ‘tails-up’ capnograph

Temperature Independence of an Electro Acoustic Capnograph

End tidal carbon dioxide measurement with an electro acoustic sensor has recently been demonstrated. The sensor consists of an acoustic resonator coupled to a low cost electro acoustic element. The aim of this study was to verify if ambient temperature variation would affect the measurements. By simultaneous measurements with a reference sensor, the electro acoustic capnograph was tested on sub...

The dromedary sign--an unusual capnograph tracing.

ABNORMAL capnographs are not unusual in clinical anesthesia. These typically result from uneven ventilation in patients with lung disease. Previous reports also have noted abnormal capnograph tracings resulting from loose connections between the end-tidal carbon dioxide sample line and the gas analyzer or other leaks in the system. The resulting biphasic waveform has been described as a long lo...

Another Half of the Double Life

Nuclear receptor regulation gears up another Notch

In this perspective we describe examples of crosstalk between nuclear receptors (NRs) and Notch signaling by means of direct functional interactions between components of both pathways. This crosstalk may provide eukaryotic organisms with molecular mechanisms for the coordination of llong-distance endocrine signals with cell-to-cell juxtacrine communication.

Tails of histones in DNA double-strand break repair.

DNA double-strand breaks (DSBs) are, arguably, the most deleterious form of DNA damage. An increasing body of evidence points to the inaccurate or inefficient repair of DSBs as a key step in tumorigenesis. Therefore, it is of great importance to understand the processes by which DSBs are detected and repaired. Clearly, these events must take place in the context of chromatin in vivo, and recent...